The ADC 2 offers convenience, safety, and reproducibility for isocratic developments of  20 x 10 cm HPTLC glass plates in full compliance with Ph. Eur. Chapter 2.8.25 and USP Chapter <203>.

The ADC 2 is a device for reproducible plate development. It performs the development step fully automated, and independent of environmental effects. The activity and pre-conditioning of the layer, chamber saturation, developing distance and final drying can be preset and automatically monitored by the ADC 2. Two modes of operation are possible: stand-alone with input of parameters via keypad, or remote operation from visionCATS with process monitoring, documentation of operating parameters, and reporting.

With visionCATS the ADC 2 can be IQ/OQ qualified and used in a cGMP environment. Operated with the mentioned software, the ADC 2 supports compliance with 21 CFR Part 11.

Key Features

The ATS 4 is a device for fully automated sample application onto TLC and HPTLC plates. Samples can be applied as bands, spots or rectangles.

Automatic sample application is a key factor for productivity of the HPTLC laboratory. The ATS 4 offers fully automatic sample application for qualitative and quantitative analyses as well as for preparative separations. It is suited for routine use and high sample throughput.

Key Features

Application of up to 75 samples as bands onto HPTLC glass plates (20 x 10 cm).

The HPTLC PRO Module APPLICATION is part of the CAMAG® HPTLC PRO SYSTEM – the first fully automated HPTLC system worldwide.

The HPTLC PRO Module APPLICATION is designed for highly precise application of samples as bands onto HPTLC glass plates. Controlled by the CAMAG® HPTLC Software visionCATS, the autonomous application of up to 75 samples is supported (on up to five HPTLC plates).

Users have the choice to operate a module as stand-alone or as part of the HPTLC PRO SYSTEM. If two or more modules are connected to form a system, a conveyor moves the HPTLC plate from one module to the other.

Key Features

Key Benefits

• Highly precise application zones through optimized spraying procedure adapted for each sample solvent
• Advanced cleaning capacities (two rinsing solutions)
• Improved cleaning procedure and application strategy to prevent cross contamination
• Minimized sample and solvent consumption.

The HPTLC PRO Module DERIVATIZATION is part of the CAMAG® HPTLC PRO SYSTEM – the first fully automated HPTLC system worldwide. The HPTLC PRO Module DERIVATIZATION is designed for the fully automatic derivatization of HPTLC glass plates (20 x 10 cm) and uniquely combines two steps in a single device: high-precision spraying of derivatization reagents and heating of the plate.

Employing the patented micro-droplet spraying technology, the Module DERIVATIZATION enables maximum homogeneity in applying derivatization reagents. The integrated plate heating unit ensures a uniform heat distribution across the plate. To suit the viscosity of the spraying reagents, four different nozzles are available. Spraying at slightly reduced pressure further improves the spraying process. Equipped with a fully automated nozzle changer and cleaning station, the Module DERIVATIZATION effectively avoids cross-contamination.

Key Features

• Part of the fully automated HPTLC PRO SYSTEM
• Nozzle changer to choose nozzles from three different nozzle parking positions
• Integrated plate heating unit
• Handling of two different reagents
• HPTLC glass plates (20 x 10 cm)
• Software-controlled by visionCATS Key Benefits
• Spraying and heating in a single device
• Maximum homogeneity in reagent and heat distribution
• Highest user safety through automation and fume hood connection
• Optimal cleaning procedure between nozzle changes
• Low reagent consumption (3 mL)

The HPTLC PRO Module DETECTION (EXPECTED 2025) is part of the CAMAG® HPTLC PRO SYSTEM – the first fully automated HPTLC system worldwide. The HPTLC PRO Module DETECTION – anticipated launch in 2024 – employs hyperspectral imaging technology to characterize and quantify all analytes. The CAMAG® HPTLC Software visionCATS allows you to prepare an unlimited number of analysis files, which can be used sequentially. As a part of the CAMAG® HPTLC PRO SYSTEM, the Module DETECTION shares several components with the other modules and has a similar design. Users have the choice to operate a module as stand-alone or as part of the HPTLC PRO SYSTEM. If two or more modules are connected to form a system, a conveyor moves the HPTLC plate from one module to the other.

Key Features

• Part of the fully automated sample analysis and evaluation by HPTLC PRO
• Excitation with Xenon or LED
• Detection range from 190-950 nm
• Absorbance and fluorescence measurement
• Evaluation of acquired hyperspectral data with visionCATS
• Software-controlled by visionCATS

Chamber designed to separate analytes using optimized parameters (activation and preconditioning of the HPTLC glass plate (20 x 10 cm) before, conditioning during, and drying after development).

The HPTLC PRO Module DEVELOPMENT is part of the CAMAG® HPTLC PRO SYSTEM – the first fully automated HPTLC system worldwide.

The sophisticated developing chamber of the CAMAG® HPTLC PRO Module DEVELOPMENT revolutionizes the development step: its geometry allows for the full control of the gas phase prior to and during chromatography, enabling the Module DEVELOPMENT to obtain highly reproducible analytical results, while the duration of pre-conditioning and activation of the stationary phase are significantly reduced.

Controlled by the CAMAG® HPTLC Software visionCATS, the Module DEVELOPMENT allows for the preparation of several analysis files, which can be executed sequentially, enabling the autonomous development of up to five different HPTLC glass plates (20 × 10 cm) with up to three different developing solvents. Users have the choice to operate a module as stand-alone or as part of the HPTLC PRO SYSTEM. If two or more modules are connected to form a system, a conveyor moves the HPTLC plate from one module to the other.

Key Features

Key Benefits

• Low chamber volume for better control of the gas phase
• Fast activation and pre-conditioning of the stationary phase (due to active circulation of the gas phase)
• Full control of the gas phase during development
• Sensor-controlled constant volume of the developing solvent in the chamber during development
• Significant time savings due to active gas phase handling
• Optimized cleaning procedure between different developing solvents
• User-independent reproducibility.

The HPTLC PRO Module MS-INTERFACE (EXPECTED 2025) is part of the CAMAG® HPTLC PRO SYSTEM – the first fully automated HPTLC system worldwide. The HPTLC PRO Module MS-INTERFACE – anticipated launch in 2024 – will be used to directly elute bands from the plate. Any position on the plate can be selected via the visionCATS software to be automatically eluted using its integrated elution pump.

The eluate is transferred into a MS or can be collected for further analysis offline. As a part of the CAMAG® HPTLC PRO SYSTEM, the Module MS-INTERFACE shares several components with the other modules and has a similar design. Users have the choice to operate a module as stand-alone or as part of the HPTLC PRO SYSTEM. If two or more modules are connected to form a system, a conveyor moves the HPTLC plate from one module to the other.

Key Features

• Part of the fully automated sample analysis and evaluation by HPTLC PRO
• Automated positioning of the elution head, also based on previous evaluation
• Either connected to an MS or fraction collector
• Optimal cleaning procedure between elutions
• HPTLC glass plates (20 x 10 cm)
• Integrated elution pump
• Software-controlled by visionCATS

The HPTLC PRO Module PLATE STORAGE is part of the CAMAG® HPTLC PRO SYSTEM – the first fully automated HPTLC system worldwide. Hosting two stackers for five clean and five processed HPTLC glass plates (20 × 10 cm), each, the HPTLC PRO Module PLATE STORAGE enables the autonomous operation of the HPTLC PRO SYSTEM. It is essential for sequential development of several plates (Module APPLICATION holds up to 75 samples) by providing the system with clean plates and storing the processed plates during or after analysis.

With the Module PLATE STORAGE the HPTLC PRO SYSTEM runs autonomously. This eliminates the human factor and results in the highest analytical quality and maximum reproducibility. Fully integrated in and controlled by the CAMAG® HPTLC Software visionCATS, the Module PLATE STORAGE optimizes the process time of sequential analyses through seamless loading and unloading of clean and processed plates, and, if necessary, through temporary storage of plates within a process. To avoid cross contamination of plates, the Module PLATE STORAGE features a fume extraction system for the active suction of vapors from the processed stacker.

Key Features

• Part of the fully automated HPTLC PRO SYSTEM
• Automated feeding of up to five HPTLC glass plates (20 × 10 cm) into the system
• Two stackers hold up to five clean and five processed HPTLC plates, with an active fume extraction system
• Software-controlled by visionCATS Key Benefits
• Enables the autonomous processing of up to five HPTLC plates in the HPTLC PRO SYSTEM
• One-time plate loading prior to the analyses improves workflow and efficiency
• Optimal process time through seamless plate loading and unloading
• No cross contamination of plates
• Possibility to run a sequence of analyses autonomously overnight

With the Linomat 5 samples are sprayed onto TLC/HPTLC plates in the form of bands with nitrogen or compressed air. Application is automatic, only changing the syringe (filling, inserting and rinsing) is manual. The Linomat 5 is suitable for small sample throughput.

Application is automatic, only changing the syringe (filling, inserting and rinsing) is manual.

Key Features

Software-controlled operation with visionCATS

The Linomat 5 is controlled by visionCATS, the new generation of HPTLC software. Instrument handling is now easier and more convenient. Simply select a plate format, fill in the sequence table and start working. With visionCATS, the Linomat 5 can be IQ/OQ qualified and used in a cGMP environment.

Operation in stand-alone mode

For those who use the Linomat 5 infrequently stand-alone mode is available. Up to ten methods can be entered either manually via the keypad or downloaded to the instrument from a computer running a licensed visionCATS program. In stand-alone mode the keypad is used to enter application parameters or to select a saved method.

The Nanomat 4 serves for easy application of samples in the form of spots onto TLC plates, precisely positioned and without damage to the layer. The Nanomat 4 is a device for contact transfer application using capillaries. The actual sample dosage is performed with a disposable capillary pipette, which is precisely guided, thus ensuring that the chromatogram can be documented and evaluated automatically according to a programmed pattern. The Nanomat 4 is suitable for any plate format up to 20 x 20 cm.

The Capillary pipettes are loaded into the dispenser in magazines. Capillaries of 0.5, 1, 2, and 5 μL volume are available. Each capillary size requires an appropriate dispenser magazine. With the Universal Capillary Holder capillary pipettes are taken from the dispenser, filled with sample solution and then placed against the applicator head of the Nanomat 4.

Key Features

The TLC Scanner 4 is the most advanced workstation for densitometric evaluation of TLC/HPTLC chromatograms and other planar objects.

The TLC Scanner 4 is a scanning densitometer. It measures the reflection of separated compounds in absorption and/or fluorescence mode. Controlled by visionCATS software the TLC Scanner 4 enables quantitative evaluation of the generated densitometric data. The spectral range of light from 190 to 900 nm is available for selecting single or multiple wavelengths for scanning densitometry. Detection can thus be fine-tuned to match the spectral properties of the analyte to its optimized specificity and sensitivity of the detection.

Key Features